Organoboron Compounds – chem. database
From website: “Boronic acids and their esters are highly popular synthetic intermediates in organic synthesis for their ease and efficiency of conversion to other functional groups, in metal-catalyzed cross-coupling reactions and for their unique biochemical activity. Read more…

Cystic Fibrosis (CF) affects about 30,000 people in the United States and approximately 70,000 people worldwide. Since the identification of the Cystic Fibrosis gene in 1989, researchers have known that CF results from mutations in the gene for the protein cystic fibrosis trans-membrane conductance regulator (CFTR). Read more…

CAS Registry Numbers are an important tool for substance searching. These are unique identifiers assigned by the Chemical Abstracts Service (CAS) to specific substances identified by them in the chemical literature.

CAS Numbers are not related to chemistry, are unrelated to any previous systems, and do not readily form phonetic analogs or synonyms. The numbers are simple and regular, convenient for database searches.
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The combinatorial peptide library is a powerful method in which a vast number of various peptides are synthesized.

The first use of synthetic peptide libraries was reported by Geysen et al. in 1984, using the pin method, and since then many papers describing different methods of synthesizing and screening peptide libraries have been published.

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Chemis3D is a free Java Applet for the online 3D Visualization of Molecular Models. Small molecules as well as macromolecular structures could be manipulated and rendered in a variety of styles and colors. Read more…

This year’s Nobel Prize in chemistry was awarded jointly to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki for the development of palladium-catalyzed cross coupling.

Left to Right: Richard F. Heck, Ei-ichi Negishi and Akira Suzuki
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I write to introduce new functionality on chemicalize.org

chemicalize.org is a public website for adding chemical resolution to web browsing, chemical names and chemical structure files. The service allows you to browse the web and see structures for chemical names (text) identified in the web page. Read more…

Histone deacetylases (HDACs) are enzymes that catalyze the deacetylation of lysine residues located in the NH2 terminal tails of core histones, which is associated with transcriptional silencing. There are 18 known human histone deacetylases, grouped into four classes based on the structure of their accessory domains. Class I (HDACs 1-3 and 8), II (HDACs 4-7, 9, and 10), and IV (HDAC 11) enzymes are Zn2+-dependent enzymes and are called HDACs, while class III enzymes (also known as sirtuins) are defined by their dependency on NAD+.

Histone deacetylase inhibitors (HDACis) are emerging as a new class of anticancer drugs and have been shown to alter gene transcription and exert antitumor effects such as growth arrest, differentiation, apoptosis, and inhibition of tumor angiogenesis. Read more…

A compound library is a collection of real stored chemicals and/or virtual chemical compounds. The compound library or chemical library can contain stored chemicals each of them has associated data with information such as the chemical structure, purity, quantity, and physiochemical characteristics of the compound. The virtual compound libraries consist of 2D or 3D representations of chemical compounds that are used for diverse purposes using computational methods. Read more…

Although more than 250 amino acids have been found in nature but only twenty of these are required for human growth.
These twenty amino acids are classified into two groups: nonessential and essential.
Essential amino acids must be obtained from the diet. These include threonine, leucine, lysine, methionine, valine, isoleucine, tryptophan, and phenylalanine.
One of the amino acids – histidine is called semi-essential because it is necessary for proper growth in children. Read more…